Philadelphia scientist receives American Heart Association prize for finding, testing metabolic factors that contribute to artery disease

November 04, 2012 Categories: Scientific Conferences & Meetings
LOS ANGELES, Nov. 4, 2012 – The American Heart Association today awarded its Clinical Research Prize for 2012 to Philadelphia scientist Daniel Rader, M.D., for developing new methods to identify factors regulating the metabolism of fat particles in the bloodstream and test their contributions to the development of artery disease.
Dr. Rader is the Edward S. Cooper, M.D./Norman Roosevelt and Elizabeth Meriwether McLure Professor of Medicine at the University of Pennsylvania’s Perelman School of Medicine.  He also is chief of the Philadelphia school’s Division of Translational Medicine and Human Genetics.  The scientist received the $5,000 prize during opening of the American Heart Association Scientific Sessions 2012 at the Los Angeles Convention Center. Association President Donna Arnett, Ph.D., of Birmingham, Ala., presented the annual award for excellence in clinical research.
“Dr. Rader has spent the last two decades doing outstanding work in the field of lipoprotein biology and atherosclerosis, and he is a widely recognized leader in this field,” Dr. Arnett said.  “While his research program has a solid basic science component, he has made major contributions to clinical investigation, both in large-scale-trials and targeted studies of smaller patient groups.”
In recent research, Rader has shown that the cholesterol efflux capacity of “good” HDL is strongly, inversely, associated with coronary disease, independent of HDL blood levels. 
He also has shown the potential usefulness of a drug that inhibits triglyceride transfer in lowering “bad” LDL in patients with a severe form of inherited high cholesterol.  In addirtion, Rader and his team have identified two genes linked to coronary artery disease and helped understand how the genes work. 
“Dr. Rader is a translational investigator ably overseeing clinical studies that are producing provocative new insights into the complexities of cardiovascular disease,” Dr. Arnett said.
About the American Heart Association
The American Heart Association is devoted to saving people from heart disease and stroke – America’s No. 1 and No. 4 killers. We team with millions of volunteers to fund innovative research, fight for stronger public health policies, and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800-AHA-USA1, visit  or call any of our offices around the country.
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