Pneumonia most common infection after heart surgery

Abstracts 12247 and 10041 - EMBARGOED UNTIL 9:30AM ET

November 15, 2011 Categories: Scientific Conferences & Meetings
Study Highlights:
  • Pneumonia — not infections at the site of surgical incision — is the most common serious infection after heart surgery.
  • After surgery, infections occur later than previously thought, with many after hospital discharge.
  • A separate study found that skin preparation procedures reduced infection from implanted cardiac defibrillators.
ORLANDO, FLA., Nov. 15, 2011 — Pneumonia — not a deep incision surgical site infection — is the most common serious infection after heart surgery, according to new research (Abstract 12247)  presented at the American Heart Association’s Scientific Sessions 2011.
 
The study also revealed that most infections occur about two weeks after surgery, not one week as physicians previously thought.
 
“It’s not what we expected to find,” said Michael A. Acker, M.D., the study’s lead researcher and professor and chief of cardiovascular surgery at the University of Pennsylvania Medical Center in Philadelphia, Pa. 
 
In abstract 12247, researchers analyzed more than 5,100 patients in a heart surgery registry. Patients, average age 64, were treated at nine U.S. academic medical centers and one Canadian center. The median time to major infection was 14 days after heart surgeries. Forty-three percent of all major infections occurred after hospital discharge.
 
“Half of these patients had no evidence of infection before they were discharged from the hospital,” Acker said. “Then they had to return because of the new infection. One implication is that patients must be followed more closely after discharge.”
 
In this study, which excluded patients who were infected before surgery, researchers found 761 infections: 300 were classified as major infections (occurring in 6 percent of patients) and 461 were minor (in 8.1 percent of patients).  Of the major infections:
  • Pneumonia, infection of the lungs, occurred in 2.4 percent of all patients.
  • C. difficile colitis, an intestinal infection, occurred in 1.0 percent.
  • Bloodstream infections occurred in 1.1 percent.
  • Deep-incision surgical site infections occurred in 0.5 percent.
Minor infections included urinary tract and superficial incision site infections.
 
The most commonly performed procedures were isolated coronary artery bypass graft and aortic
and mitral valve surgeries. Seventy-four percent were elective surgeries and 26 percent were non-elective or emergency surgeries.
 
Several risk factors appeared to increase the risk of developing infection, including congestive heart failure, hypertension, chronic lung disease, corticosteroid use prior to surgery, and length of cardiopulmonary bypass time.
 
“In the next level of analysis, the focus will be on differences in care, from the types of dressings, the types of antibiotics, and the types of surgical preparations, to show what processes of care are associated with decreased incidence of infections,” Acker said. “The registry will allow us to modify our best practices to manage post-operative infections.”
 
Co-authors are Michael Argenziano, M.D.; John D. Puskas, M.D., M.Sc.; T. Bruce Ferguson, M.D.; Annetine C. Gelijns, Ph.D.; Keith Horvath, M.D.; Marissa A. Miller, DVM, MPH; Stacey Welsh, R.N.; Ellen Moquete, R.N.; Kevin N. Su, B.S. Alan Weinberg, M.S.; Alan J. Moskowitz, M.D.; Patrick T. O’Gara, M.D. and Eugene H. Blackstone, M.D.
 
The National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke and Canadian Institutes of Health Research funded the study.
 
Skin preparation reduces cardiac implantable device infections
In another study (abstract 10041), special skin preparations for 3,700 patients significantly reduced infections from cardiac implantable electronic devices.
 
Researchers at a Milwaukee hospital washed patients’ skin with a special antibacterial solution the night before and morning of the procedure. They also included a strict three-minute drying time for the surgical skin preparation. These steps decreased implant infection rates from 1 percent to 0.24 percent at a year following the implant placement.
 
More staphylococcal bacterial infections are occurring after implantation procedures, said Renee Koeberl, R.N., M.S.N., lead author of the study.
 
Co-authors are Mohamed S. Rahman, M.D.; Rachel Pedersen, B.A.; Jasbir Sra, M.D.; Masood Akhtar, M.D. and M. Eyman Mortada, M.D. Author disclosures are on the abstract.
 
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Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association’s policy or position.  The association makes no representation or guarantee as to their accuracy or reliability.  The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events.  The association has strict policies to prevent these relationships from influencing the science content.  Revenues from pharmaceutical and device corporations are available at www.heart.org/corporatefunding.
 
NR11-1144 (SS11/author)
 
Notes: Actual presentation of abstract 10041 is 3 p.m. ET, Tuesday, Nov. 15.
Due to scheduling conflicts, Dr. Acker will not be available for media interview onsite and should be contacted in advance at number and email above.
 
NEW for Scientific Sessions 2011:
All downloadable video/audio interviews, B-roll, animation and images related to this news release are located on the right column of the release link 
http://newsroom.heart.org/pr/aha/_prv-pneumonia-most-common-infection-217814.aspx, along with general Sessions multimedia resources. Video clips with researchers/authors of studies will be added to the release links after embargo.   
 
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