DALLAS (Sept. 6, 2016) — The American Heart Association (AHA) and the Patient-Centered Outcomes Research Institute (PCORI) announce today a new Researcher and Clinician Challenge to identify or suggest critical but unanswered questions facing cardiovascular patients, caregivers and their healthcare providers that should be addressed through additional research. This collaboration, executed through the AHA Institute for Precision Cardiovascular Medicine, seeks to uncover questions that can be answered by studies that leverage comparative clinical effectiveness research – research comparing the benefits and harms of alternate health care methods – with a precision medicine approach that takes into account individual characteristics.

Through the Researcher and Clinician Challenge, the AHA and PCORI seek to generate research study hypotheses that address gaps in the evidence about which cardiovascular disease treatment approaches work best for which patients. This challenge follows a Patient Challenge held earlier this year that engaged thousands in an effort to uncover treatment dilemmas faced by patients and their caregivers. The top themes selected from the submissions from patients in the first challenge are carried over into the Researcher and Clinician Challenge as specific areas for respondents to expand upon. By using precision medicine approaches and techniques, we hope to enable patients and doctors together to make the best decision when considering their treatment options.

“Having gained valuable insights from patients, this opportunity to collaborate with the research and physician communities will propel the next phase of study to further the development of both comparative effectiveness research and precision cardiovascular medicine,” said Nancy Brown, American Heart Association CEO. “AHA and PCORI will transform the research paradigm by addressing critical gaps to accelerate discovery and make a difference in the lives of patients.”  

“By employing a stakeholder-driven approach to research, we’re confident that we can address the questions, concerns, and outcomes that matter most to patients and those who care for them, including clinicians,” said Joe Selby, PCORI’s Executive Director. “We look forward to as robust a response to the Researcher and Clinician Challenge as we saw during the earlier Patient Challenge.”

As the leading cause of death, with more than one in every three U.S. adults suffering some form of cardiovascular disease, this condition places significant burdens on individuals, families, the nation’s productivity and its healthcare system. Countless research opportunities remain to reduce this burden. As the U.S. population ages, the demand will increase for improved ways to allow Americans to live healthy and productive lives before and with cardiovascular disease.

Responses must be submitted here by October 6, 2016 at 11:59 p.m. EDT and should address how their proposed research questions will take into account both comparative effectiveness research and precision medicine including an individual’s genetics, environment and lifestyle.  AHA and PCORI will award four winners a cash prize of $5,000 each for submitting the top research hypotheses that will also be considered for future funding opportunities.


The Patient-Centered Outcomes Research Institute (PCORI) is an independent, nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers, and clinicians with the evidence-based information needed to make better-informed healthcare decisions. PCORI is committed to continually seeking input from a broad range of stakeholders to guide its work. More information is available at www.pcori.org.

About the AHA Institute for Precision Cardiovascular Medicine
The American Heart Association Institute for Precision Cardiovascular Medicine aims to preserve and prolong health by more precisely predicting, preventing and treating cardiovascular diseases and stroke. To further advance our mission and Institute's goals, we offer funding opportunities to scientists of all fields. To learn more or to get involved, visit http://institute.heart.org.

About the American Heart Association
The American Heart Association is devoted to saving people from heart disease and stroke – the two leading causes of death in the world. We team with millions of volunteers to fund innovative research, fight for stronger public health policies, and provide lifesaving tools and information to prevent and treat these diseases. The Dallas-based association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke. To learn more or to get involved, call 1-800- AHA-USA1, visit heart.org or call any of our offices around the country. Follow us on Facebook and Twitter.

For Media Inquiries

American Heart Association: Jennifer Pratt, 214.706.2229, Jennifer.Pratt@heart.org

Patient-Centered Outcomes Research Institute: info@pcori.org