Research Highlights:

  • Steady progress in reducing the rates of premature cardiac death in the U.S. began slowing in 2011, largely due to rising rates of out-of-hospital premature cardiac deaths, especially among younger adults.
  • County-level disparities in premature cardiac death rates across the U.S. have widened over the past two decades.

Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, July 29, 2020                                                                                                                   

DALLAS, July 29, 2020 — After decades of progress in reducing overall, premature cardiac death rates in the U.S., a county-by-county population study has found the decline began slowing in 2011, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

Researchers in China and the U.S. accessed multiple databases to analyze county-by-county data on nearly 1.6 million premature cardiac deaths in the U.S. that occurred between 1999 and 2017, among individuals between 35 and 74 years of age. While rates declined between 1999 and 2017, since 2010 the pace of the decline has slowed significantly.

“From the 1960s to 2010s, the United States experienced remarkable decline in cardiovascular disease mortality that was coined as one of the major public health accomplishments of the 20th century,” said lead investigator Zhi-Jie Zheng, M.D., Ph.D., a University Endowed Distinguished Professor and chair of the department of global health at Peking University in Beijing, China, who leads studies analyzing global and country-specific trends in diseases of major global health importance. Zheng previously served as a lead epidemiologist at the U.S. Centers for Disease Control and Prevention in Atlanta and a supervisory medical epidemiologist at the National Heart, Lung, and Blood Institute of the National Institutes of Health in Bethesda, Maryland.

“Increasing numbers of out-of-hospital deaths and fatal heart attacks in younger age groups, coupled with a steady widening of disparity of socioeconomic and health environment factors affecting health care at the county level, appear to be the key drivers of the slowdown we have seen since 2010.”

The study is one of the first national analyses on factors related to disparities in premature cardiac death rates among U.S. counties.

In 2012, all United Nations-member countries including the U.S. committed to achieving a 25% reduction in premature death from cardiovascular diseases, cancer, diabetes or chronic respiratory diseases by the year 2025, as proposed by World Health Organization (WHO). In addition, The Global Cardiovascular Disease Taskforce, which includes the American Heart Association, American College of Cardiology Foundation and other organizations, set a goal to reducing premature deaths from cardiovascular diseases and stroke (The Heart of 25 by 25).

In this study, premature cardiac death was defined as any death that occurred between ages 35 and 74 attributed to heart disease. Among the key findings:

  • Of nearly 1.6 million premature cardiac deaths from 1999 to 2017, about 61% occurred outside of a hospital.
  • Although overall premature cardiac death rates fell, the proportion of out-of-hospital deaths rose from 58.3% to 61.5% in 2017.
  • Twice as many premature cardiac deaths occurred in men compared to women.
  • Premature death rates were 3.4 times higher among African Americans than Asians or Pacific Islanders.

“Our findings suggest a need for health care policy changes and programs that can identify high-risk, young populations prone to premature cardiac death and support improved cardiac health,” Zheng said.

“The decline in the reduction of premature deaths attributable to heart disease is disheartening and is an urgent call to action,” said American Heart Association President Mitchell S. V. Elkind, M.D., M.S., FAHA, FAAN, professor of neurology and epidemiology at Columbia University New York and attending neurologist at Columbia University Irving Medical Center of the NewYork-Presbyterian Hospital. “We must invest and focus public and private efforts to address the disparities in risk factors, access to care and other factors slowing the progress in heart disease so that we can increase the opportunity for all Americans to live longer and healthier lives.”

“Heart attacks can occur at any age, not just in older persons,” Zheng said. “The slower decline in out-of-hospital rates is alarming and warrants more precision targeting and sustained efforts to integrate lifestyle and behavioral interventions that increase heart health and reduce the risk of premature cardiac death.”

Disparities were largely associated with demographic composition and socioeconomic status. Demographic composition, which included population size, rural living, sex, age, racial/ethnic and foreign-born as factors, accounted for just over a third of out-of-hospital and in-hospital premature cardiac deaths.

Differences in socioeconomic factors, which included median household income, unemployment, school enrollment and number of violent crimes per 100,000 population, accounted for about 20% of deaths.

Health care environment, which included density of primary care physicians; diabetic, Medicare enrollees who had diabetes confirmed by an HbA1c test; access to places for physical activity; and access to healthy foods, accounted for 18.6% of out-of-hospital and 13.9% of in-hospital deaths. While population health status, which included scoring according to the cardiovascular disease risk index derived from a set of major cardiovascular risk factors, self-rated poor/fair health and total Medicare reimbursements per enrollee (a measure of health care utilization as a proxy for illness), accounted for 23.7% of out-of-hospital death and 30.2% in-hospital deaths.

The study had several limitations including potential errors in the reporting of cause of death, which is reliant on county-level, government health department data.

Co-authors are Yinzi Jin, Ph.D.; Suhang Song, Ph.D.; Lin Zhang, M.D., Ph.D.; Michael G. Trisolini, Ph.D.; Kenneth A. Labresh, M.D.; and Sidney C. Smith, Jr., M.D. The authors reported no conflicts of interest or financial disclosures. The research was funded by the National Natural Science Foundation of China and the Beijing Municipal Science Foundation.

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