Moderate exercise cuts women’s stroke risk, helps offset increase risk from hormone therapy

American Stroke Association Meeting Report: Abstract: TMP67 (Room Hall G)

February 13, 2014 Categories: Scientific Conferences & Meetings, Stroke News

Study Highlights:

  • Moderate exercise like brisk walking may cut women’s stroke risk 20 percent.
  • Moderate exercise also helps offset some of the increased stroke risk in women taking postmenopausal hormone therapy.
Embargoed until 8 a.m. PT/11 a.m. ET Thursday, Feb. 13, 2014
This study is being featured in a news conference at 8 a.m. PT Thursday, Feb. 13.

SAN DIEGO, Feb. 13, 2014 — Women don’t need to run marathons or do intense aerobics to reduce their stroke risk. Moderate-intensity exercise — such as brisk walking or playing tennis -- may do the trick, according to research presented at the American Stroke Association’s International Stroke Conference 2014.

“I was surprised that moderate physical activity was most strongly associated with a reduced risk of stroke,” said Sophia Wang, Ph.D., the study’s lead author and professor in the department of population sciences within the Beckman Research Institute at the City of Hope in Duarte, Calif. “More strenuous activity such as running didn’t further reduce women’s stroke risk. Moderate activity, such as brisk walking appeared to be ideal in this scenario.”

The study found that moderate exercise also helps offset the increased stroke risk seen with postmenopausal women taking menopausal hormones, but not completely.

Researchers analyzed information from the 133,479 women in the California Teachers Study to see how many suffered a stroke between 1996 and 2010. Those who reported doing moderate physical activity in the three years before enrolling in the study were 20 percent less likely than women who reported no activity to suffer a stroke. “The benefits of reducing risk of stroke were further observed among the group of women who had a sustained moderate level of physical activity over time,” she said.

Postmenopausal women taking menopausal hormone therapy had more than a 30 percent higher risk of stroke than women who never used menopausal hormone therapy. After the women stopped taking hormones, their risk began to diminish.

“The effects of physical activity and hormone therapy appear immediate and the benefits of physical activity are consistent in premenopausal and postmenopausal women,” Wang said. Therefore, Wang recommends that women incorporate some type of physical activity into their daily routine. “You don’t have to do an extreme boot camp. The types of activities we’re talking about are accessible to most of the population.” Power walking and recreational tennis, for example, do not necessarily require special memberships to gyms.

The study also found that women with diabetes had elevated stroke risk, although this group encompassed women who also were overweight. “Physical activity, obesity and diabetes are all highly correlated with one another,” Wang said. “Stroke prevention among diabetics is thus a particularly important scientific question to address.”

Although 87 percent of the women were white, Wang said she believes the study’s results may also apply to women in other racial/ethnic groups because the amount of stroke risk reduction was so robust. Further studies are needed to determine how much moderate exercise helps those with diabetes avoid strokes.

Co-authors are: Leslie Bernstein, M.S., Ph.D.; James Lacey, Jr., M.P.H., Ph.D.; Kamakshi Lakshminarayan, M.D., Ph.D. Mitchell Elkind, M.D., M.S., M.Phil; Daniel Woo, M.D.; Ph.D.; Jenna Voutsinas, M.P.H.; and Chengyi Zhong, M.P.H.

Author disclosures are on the abstract.

The study was funded by the National Institute of Neurological Disorders and Stroke. The California Teachers Study group is funded by the National Cancer Institute.

Get additional information on:

women’s stroke risk

ASA’s Together To End Stroke program

physical activity

Note: The American Heart Association does not recommend using postmenopausal hormone therapy to reduce the risk of coronary heart disease or stroke because some studies have shown it does not reduce the risk. Read more about menopause and heart disease.


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Note: Actual presentation time is 5:45 p.m. PT on Thursday, Feb. 13, 2014.

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