• To date, no adverse cardiac events related to SARS-CoV-2 infection have been observed among more than 3,000 collegiate athletes during short-term clinical surveillance.
  • Findings suggest safe return-to-play without cardiac testing for asymptomatic or mildly symptomatic athletes.

DALLAS, April 17, 2021 — While the lasting impact of COVID-19 on hospitalized patients in the general population is common and associated with adverse cardiac outcomes, evaluations of cardiac involvement of more than 3,000 college-aged, competitive athletes revealed no adverse cardiac events following COVID-19 infections and indicate a safe return-to-play for asymptomatic and mildly symptomatic athletes without additional cardiac testing, according to a study published today in the American Heart Association’s flagship journal Circulation

In this prospective, multicenter, observational cohort study with data collected from September 1 to December 31, 2020, from 42 colleges and universities in the U.S., researchers assessed the prevalence, clinical characteristics and outcomes of SARS-CoV-2 cardiac involvement among collegiate athletes using the Outcomes Registry for Cardiac Conditions in Athletes (ORCCA). ORCCA is a national registry, or research database, to track COVID-19 cases and heart-related impacts in NCAA athletes to drive improvements in screening and inform our understanding of cardiac involvement in college athletes who have had COVID-19.

“The very timely and largely reassuring data coming from the ORCCA registry were made possible by an amazing collaborative effort between the sports medicine and sports cardiology communities,” said Aaron L. Baggish, M.D., co-principal investigator and director of the Cardiovascular Performance Program at Massachusetts General Hospital in Boston. “It is anticipated that ORCCA will continue to shape the way we protect the health of young competitive athletes well beyond the end of the COVID-19 pandemic.”

Out of more than 19,000 athletes tested for SARS-CoV-2 infection, 3,018 tested positive for  COVID-19 and underwent cardiac evaluation. A total of 2,820 athletes underwent at least one element of cardiac ‘triad’ testing (12-lead electrocardiography (ECG), troponin, and/or transthoracic echocardiography(TTE)), followed by cardiac magnetic resonance (CMR) if clinically indicated; and 198 athletes underwent a primary screening CMR.

Overall, the prevalence of probable or definite cardiac involvement from SARS-CoV-2 infection was 0.4%-1.5%. The diagnostic yield for probable or definite cardiac involvement was 6.7 times higher for a CMR obtained for clinical reasons (10.1%) versus a primary screening CMR (1.5%). The odds of having cardiac involvement was also 3.1 times higher in athletes with cardiopulmonary symptoms.

“This was an amazing collaboration within the sports medicine and cardiology community,” said Jonathan A. Drezner, M.D., director of the UW Medicine Center for Sports Cardiology in Seattle and a co-principal investigator of the study. “Most athletes with no symptoms or mild illness from SARS-CoV-2 can return to sports safely without additional cardiac testing as long as they feel good on return to exercise and don’t have cardiopulmonary symptoms like chest pain.”

The American Heart Association and the American Medical Society for Sports Medicine (AMSSM) joined forces earlier this year to accelerate a critical new research initiative studying cardiac conditions in athletes, in part to speed new insights into the impact of COVID-19 to the cardiovascular system of college athletes and safety of return to play after diagnosis. The collaborative data registry will aid research on COVID-19, and, long-term, develop a deep knowledge base on cardiac disease in athletes beyond the pandemic. The registry has been developed with participation from the NCAA and has more than 60 schools currently contributing to the registry.

Schools interested in participating or learning more about the registry can send an inquiry to: ncaa.cardiac@mgh.harvard.edu.

The research team is led by three primary investigators:

  • Jonathan A. Drezner, M.D., Department of Family Medicine, Center for Sports Cardiology, University of Washington School of Medicine, Seattle
  • Kimberly G. Harmon, M.D., Department of Family Medicine, Center for Sports Cardiology, University of Washington School of Medicine, Seattle
  • Aaron L. Baggish, M.D., Cardiovascular Performance Program, Massachusetts General Hospital, Boston

The following Circulation link is available for posting in news articles and will be live after embargo:  https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.054824

Additional resources:

Statements and conclusions of studies published in the American Heart Association’s scientific journals are solely those of the study authors and do not necessarily reflect the Association’s policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers are available here, and the Association’s overall financial information is available here.

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public’s health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for nearly a century. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1.   

About the AMSSM

AMSSM is a multi-disciplinary organization of sports medicine physicians dedicated to education, research, advocacy and the care of athletes of all ages. The majority of AMSSM members are primary care physicians with fellowship training and added qualification in sports medicine who then combine their practice of sports medicine with their primary specialty. AMSSM includes members who specialize solely in non-surgical sports medicine and serve as team physicians at the youth level, NCAA, NFL, MLB, NBA, WNBA, MLS and NHL, as well as with Olympic and Paralympic teams. By nature of their training and experience, sports medicine physicians are ideally suited to provide comprehensive medical care for athletes, sports teams or active individuals who are simply looking to maintain a healthy lifestyle. www.amssm.org



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