Research Highlights:

  • The intensive care unit (ICU) admission of one spouse can be a risk factor for a cardiovascular event for the other spouse within a few weeks after the first spouse’s ICU hospitalization.
  • In this review of a Japanese medical database, spouses of patients admitted to the ICU for more than two days were themselves more likely to visit a doctor or be hospitalized for a cardiovascular reason compared to people without a spouse in the ICU.

Embargoed until 4 a.m. CT/5 a.m. ET Monday, Oct. 5, 2020

DALLAS, Oct. 5, 2020 — Having a spouse in a hospital’s intensive care unit (ICU) may make a person more likely to have a heart attack or cardiac-related hospitalization themselves within a few weeks of the ICU admission, according to new research published today in the American Heart Association’s flagship journal Circulation.

“Spouses of ICU patients should pay attention to their own physical health, especially in terms of cardiovascular disease,” said the study’s senior author Hiroyuki Ohbe, M.D., M.P.H., a Ph.D. student in the department of clinical epidemiology and health economics in the School of Public Health at The University of Tokyo in Japan. “The ICU can be a stressful environment with significant caregiving burdens, and spouses may face tough decisions about continuing or ending life-sustaining treatment.”

“A patient’s admission to ICU puts acute psychological stress on family members, and that stress may increase the risk for cardiovascular disease particularly for the other spouse,” Ohbe said.

This study is the first to suggest ICU admission of a spouse may be a risk factor for cardiovascular disease events and hospitalization in the other spouse. According to previous research, about a quarter to one-half of family members of a critically ill patient experience symptoms of post-traumatic stress, anxiety and depression, known as “post-intensive care syndrome-family.” Studies about bereavement have shown an increased risk of cardiovascular diseases particularly in the early weeks and months after a loved one has died, known as broken-heart syndrome (also called stress-induced cardiomyopathy or takutsobo cardiomyopathy).

Researchers matched spouses of patients admitted to the ICU for more than two days with people randomly selected from the Japan Medical Data Center database of 6 million inpatient and outpatient health insurance claims between January 2005 and August 2018.

Among 2.1 million people (just over one million married couples), more than 7,800 spouses of patients admitted to ICUs were matched with more than 31,000 people randomly selected from the database. The average age of the spouses  was 54, and 35% were men. The two groups were matched for sex, age and medical insurance status.

Researchers evaluated data for any visit for cardiovascular disease, hospitalization for cardiovascular diseases and severe cardiovascular events. Compared to people without a spouse in the ICU, those with a husband or wife in the ICU:

  • had increased odds of having a cardiovascular event, such as chest pain, heart attack, stroke, irregular heart rhythm, heart failure or pulmonary embolism (a blood clot in the lungs) within a month; and
  • were more likely to be hospitalized for cardiovascular diseases and hospitalized for severe cardiovascular events.

Because the database includes only patients with employment health insurance, it may limit the ability to generalize the findings to other populations such as older adults or those without insurance. The findings should also be applicable to U.S. adults who have health insurance.

Previous studies and the current American College of Critical Care Medicine guidelines on care for family members of ICU patients have focused mostly on mental health, researchers noted. No studies have examined the physical health risks for family members. More studies are needed to confirm the findings of this research and to explore if behavior adjustments during this stressful time, such as changes in social ties, living arrangements, eating habits, alcohol consumption and economic support, are factors.

Co-authors are Tadahiro Goto, M.D., M.P.H., Ph.D.; Yuki Miyamoto, M.D.; and Hideo Yasunaga, M.D., Ph.D. No disclosures were reported.

Japan’s Ministry of Health, Labour and Welfare; and the Ministry of Education, Culture, Sports, Science and Technology of Japan funded the study.

Additional Resources:

Statements and conclusions of studies published in the American Heart Association’s scientific journals are solely those of the study authors and do not necessarily reflect the Association’s policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers are available here, and the Association’s overall financial information is available here

About the American Heart Association

The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public’s health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for nearly a century. Connect with us on, Facebook, Twitter or by calling 1-800-AHA-USA1.


For Media Inquiries and AHA/ASA Expert Perspective: 214-706-1173

Bridgette McNeill:

For Public Inquiries: 1-800-AHA-USA1 (242-8721) and